Intrinsic Pathway (Last Updated - 2/27/2005)

-involves prekallikrein, high molecular weight kininogen (HMWK), kaolin, Factors XII, XIIa, XI, XIa, IX, IXa, VIII & VIIIa
-a deficiency of any of the above factors will lead to prolongation of the aPTT

-click here to view an image of the clotting cascade

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References:

Goodman & Gilman's: The Pharmacologic Basis Of Therapeutics - 10th Edition - 2001. Chapter 55.