Intrinsic Pathway (Last Updated - 2/27/2005)
-involves prekallikrein, high molecular weight kininogen (HMWK), kaolin, Factors
XII, XIIa, XI, XIa, IX,
IXa, VIII & VIIIa
-a deficiency of any of the above factors will lead to prolongation of the aPTT
-click here to view an image of the clotting cascade
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References:
Goodman & Gilman's: The Pharmacologic Basis Of Therapeutics - 10th Edition - 2001. Chapter 55.